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alchemical free energy calculationsbiomolecular modelingcoronavirusCOVID-19foldingathomehealthlife sciencesmolecular dynamicsproteinSARS-CoV-2simulationsstructural biology
Folding@home is a massively distributed computing project that uses biomolecular simulations to investigate the molecular origins of disease and accelerate the discovery of new therapies. Run by the Folding@home Consortium, a worldwide network of research laboratories focusing on a variety of different diseases, Folding@home seeks to address problems in human health on a scale that is infeasible by another other means, sharing the results of these large-scale studies with the research community through peer-reviewed publications and publicly shared datasets. During the COVID-19 epidemic, Folding@home focused its resources on understanding the vulnerabilities in SARS-CoV-2, the virus that causes COVID-19 disease, and working closely with a number of experimental collaborators to accelerate progress toward effective therapies for treating COVID-19 and ending the pandemic. In the process, it created the world's first exascale distributed computing resource, enabling it to generate valuable scientific datasets of unprecedented size. More information about Folding@home's COVID-19 research activities at the Folding@home COVID-19 page. In addition to working directly with experimental collaborators and rapidly sharing new research findings through preprint servers, Folding@home has joined other researchers in committing to rapidly share all COVID-19 research data, and has joined forces with AWS and the Molecular Sciences Software Institute (MolSSI) to share datasets of unprecedented side through the AWS Open Data Registry, indexing these massive datasets via the MolSSI COVID-19 Molecular Structure and Therapeutics Hub. The complete index of all Folding@home datasets can be found here. Th...
bambioinformaticsbiologycoronavirusCOVID-19fast5fastafastqgeneticgenomichealthjsonlife scienceslong read sequencingmedicineMERSmetadataopen source softwareRDFSARSSARS-CoV-2SPARQL
COVID-19 PubSeq is a free and open online bioinformatics public sequence resource with on-the-fly analysis of sequenced SARS-CoV-2 samples that allows for a quick turnaround in identification of new virus strains. PubSeq allows anyone to upload sequence material in the form of FASTA or FASTQ files with accompanying metadata through the web interface or REST API.
bamCOVID-19geneticgenomiclife sciencesMERSSARSSARS-CoV-2virus
Serratus is a collaborative open science project for ultra-rapid discovery of known and unknown coronaviruses in response to the COVID-19 pandemic through re-analysis of publicly available genomic data. Our resulting vertebrate viral alignment data is explorable via the Serratus Explorer and directly accessible on Amazon S3.
coronavirusCOVID-19life sciences
A harmonized collection of the core data pertaining to COVID-19 reported cases by geography, in a format prepared for analysis
computed tomographycomputer visioncoronavirusCOVID-19grand-challenge.orgimaginglife sciencesSARS-CoV-2
The STOIC project collected Computed Tomography (CT) images of 10,735 individuals suspected of being infected with SARS-COV-2 during the first wave of the pandemic in France, from March to April 2020. For each patient in the training set, the dataset contains binary labels for COVID-19 presence, based on RT-PCR test results, and COVID-19 severity, defined as intubation or death within one month from the acquisition of the CT scan. This S3 bucket contains the training sample of the STOIC dataset as used in the STOIC2021 challenge on grand-challenge.org.
amazon.sciencebioinformaticsbiologycoronavirusCOVID-19healthlife sciencesmedicineMERSSARS
A centralized repository of up-to-date and curated datasets on or related to the spread and characteristics of the novel corona virus (SARS-CoV-2) and its associated illness, COVID-19. Globally, there are several efforts underway to gather this data, and we are working with partners to make this crucial data freely available and keep it up-to-date. Hosted on the AWS cloud, we have seeded our curated data lake with COVID-19 case tracking data from Johns Hopkins and The New York Times, hospital bed availability from Definitive Healthcare, and over 45,000 research articles about COVID-19 and rela...
COVID-19economicsfinancial marketshiringmarket data
This dataset provides daily updates on the volume of US job listings filtered by geography industry job family and role; normalized to pre-covid levels.These data files feed the business intelligence visuals at covidjobimpacts.greenwich.hr, a public-facing site hosted by Greenwich.HR and OneModel Inc. Data is derived from online job listings tracked continuously, calculated daily and published nightly. On average data from 70% of all new US jobs are captured, and the dataset currently contains data from 3.3 million hiring organizations.Data for each filter segment is represented as the 7-day ...
bambioinformaticscoronavirusCOVID-19fastafastqgeneticgenomicglobalhealthlife scienceslong read sequencingSARS-CoV-2vcfviruswhole genome sequencing
The Sequence Read Archive (SRA) is the primary archive of high-throughput sequencing data, hosted by the National Institutes of Health (NIH). The SRA represents the largest publicly available repository of SARS-CoV-2 sequencing data. This dataset was created by DNAstack using SARS-CoV-2 sequencing data sourced from the SRA. Where possible, raw sequence data were processed by DNAstack through a unified bioinformatics pipeline to produce genome assemblies and variant calls. The use of a standardized workflow to produce this harmonized dataset allows public data generated using different methodol...
amino acidarchivesbioinformaticsbiomolecular modelingcell biologychemical biologyCOVID-19electron microscopyelectron tomographyenzymelife sciencesmoleculenuclear magnetic resonancepharmaceuticalproteinprotein templateSARS-CoV-2structural biologyx-ray crystallography
The "Protein Data Bank (PDB) archive" was established in 1971 as the first open-access digital data archive in biology. It is a collection of three-dimensional (3D) atomic-level structures of biological macromolecules (i.e., proteins, DNA, and RNA) and their complexes with one another and various small-molecule ligands (e.g., US FDA approved drugs, enzyme co-factors). For each PDB entry (unique identifier: 1abc or PDB_0000001abc) multiple data files contain information about the 3D atomic coordinates, sequences of biological macromolecules, information about any small molecules/ligan...
coronavirusCOVID-19information retrievallife sciencesnatural language processingtext analysis
The REaltime DAta Synthesis and Analysis (REDASA) COVID-19 snapshot contains the output of the curation protocol produced by our curator community. A detailed description can be found in our paper. The first S3 bucket listed in Resources contains a large collection of medical documents in text format extracted from the CORD-19 dataset, plus other sources deemed relevant by the REDASA consortium. The second S3 bucket contains a series of documents surfaced by Amazon Kendra that were considered relevant for each medical question asked. The final S3 bucket contains the GroundTruth annotations cr...
bambioinformaticsbiologycoronavirusCOVID-19cramfastqgeneticgenomichealthlife sciencesMERSSARSSTRIDEStranscriptomicsviruswhole genome sequencing
This repository within the ACTIV TRACE initiative houses a comprehensive collection of datasets related to SARS-CoV-2. The processing of SARS-CoV-2 Sequence Read Archive (SRA) files has been optimized to identify genetic variations in viral samples. This information is then presented in the Variant Call Format (VCF). Each VCF file corresponds to the SRA parent-run's accession ID. Additionally, the data is available in the parquet format, making it easier to search and filter using the Amazon Athena Service. The SARS-CoV-2 Variant Calling Pipeline is designed to handle new data every six ho...
coronavirusCOVID-19life sciencesMERSSARS
Full-text and metadata dataset of COVID-19 and coronavirus-related research articles optimized for machine readability.
bioinformaticsbiologycoronavirusCOVID-19life sciencesmolecular dockingpharmaceutical
Aggregating critical information to accelerate drug discovery for the molecular modeling and simulation community. A community-driven data repository and curation service for molecular structures, models, therapeutics, and simulations related to computational research related to therapeutic opportunities for COVID-19 (caused by the SARS-CoV-2 coronavirus).
bioinformaticscoronavirusCOVID-19healthlife sciencesmedicineSARS
This dataset is a collection of anonymized thoracic radiographs (X-Rays) and computed tomography (CT) scans of patients with suspected COVID-19. Images are acommpanied by a positive or negative diagnosis for SARS-CoV2 infection via RT-PCR. These images were provided by Hospital das Clínicas da Universidade de São Paulo, Hospital Sirio-Libanes, and by Laboratory Fleury.