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UK Biobank Pharma Proteomics Project (UKB-PPP)

genome wide association study population genetics


The UKB-PPP is a collaboration between the UK Biobank (UKB) and thirteen biopharmaceutical companies characterising the plasma proteomic profiles of 54,219 UKB participants. As part of a collaborative analysis across the thirteen UKB-PPP partners, we conducted comprehensive protein quantitative trait loci (pQTL) mapping of 2,923 proteins that identifies 14,287 primary genetic associations, of which 85% are newly discovered, in addition to ancestry-specific pQTL mapping in non-Europeans. We identify independent secondary associations in 87% of cis and 30% of trans loci, expanding the catalogue of genetic instruments for downstream analyses.

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Managed By

Sage Bionetworks

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How to Cite

UK Biobank Pharma Proteomics Project (UKB-PPP) was accessed on DATE from Sun, B.B., Chiou, J., Traylor, M. et al. Plasma proteomic associations with genetics and health in the UK Biobank. Nature 622, 329–338 (2023).

Usage Examples


Resources on AWS

  • Description
    Population-specific GWAS summary statistics per protein measurement, as well as meta-data for annotating protein measurements and genetic variants.
    Resource type
    S3 Bucket Controlled Access
    Amazon Resource Name (ARN)
    AWS Region

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