Therapeutically Applicable Research to Generate Effective Treatments (TARGET) is the collaborative effort of a large, diverse consortium of extramural and NCI investigators. The goal of the effort is to accelerate molecular discoveries that drive the initiation and progression of hard-to-treat childhood cancers and facilitate rapid translation of those findings into the clinic.
TARGET projects provide comprehensive molecular characterization to determine the genetic changes that drive the initiation and progression of childhood cancers.The dataset contains open Clinical Supplement, Biospecimen Supplement, RNA-Seq Gene Expression Quantification, miRNA-Seq Isoform Expression Quantification, miRNA-Seq miRNA Expression Quantification data from Genomic Data Commons (GDC), and open data from GDC Legacy Archive.
Genomic Data Commons (GDC) is source of truth for this dataset; GDC offers monthly data releases,
although this dataset may not be updated at every release.
NIH Genomic Data Sharing Policy: https://gdc.cancer.gov/access-data/data-access-policies
See all datasets managed by Center for Translational Data Science at The University of Chicago.
How to Cite
Therapeutically Applicable Research to Generate Effective Treatments (TARGET) was accessed on
DATE from https://registry.opendata.aws/target.
Tools & Applications
A Children's Oncology Group and TARGET initiative exploring the genetic landscape of Wilms
by Gadd S, Huff V, Walz AL, et al.
Ancestry and pharmacogenomics of relapse in acute lymphoblastic leukemia by Yang JJ, Cheng C, Devidas M, et al.
Biomarker significance of plasma and tumor miR-21, miR-221, and miR-106a in osteosarcoma
by Nakka M, Allen-Rhoades W, Li Y, et al.
CSF3R mutations have a high degree of overlap with CEBPA mutations in pediatric AM by Maxson JE, Ries RE, Wang YC, et al.
Genetic predisposition to neuroblastoma mediated by a LMO1 super-enhancer polymorphism by Oldridge DA, Wood AC, Weichert-Leahey N, Crimmins I, Sussman R, Winter C, McDaniel LD,
Diamond M, Hart LS, Zhu S, Durbin AD, Abraham BJ, et al.
Genome-Wide Profiles of Extra-cranial Malignant Rhabdoid Tumors Reveal Heterogeneity and
Dysregulated Developmental Pathways
by Chun HJ, Lim EL, Heravi-Moussavi A, et al.
Genomic classification and identification of the cell of origin of pediatric mixed phenotype
by Thomas B. Alexander, Zhaohui Gu, Ilaria Iacobucci, et al.
Genomics in childhood acute myeloid leukemia comes of age by Brunner AM, Graubert TA.
Identification and analyses of extra-cranial and cranial rhabdoid tumor molecular subgroups
reveal tumors with cytotoxic T cell infiltration
by Hye-Jung E. Chun, Pascal D. Johann, Katy Milne et al.
MicroRNA Expression-Based Model Indicates Event-Free Survival in Pediatric Acute Myeloid
by Lim EL, Trinh DL, Ries RE, et al.
MLLT1 YEATS domain mutations in clinically distinctive Favourable Histology Wilms tumours
by Perlman EJ, Gadd S, Arold ST, et al.
Recurrent DGCR8, DROSHA, and SIX homeodomain mutations in favorable histology Wilms tumors
by Walz AL, Ooms A, Gadd S, et al.
Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations by Eleveld TF, Oldridge DA, Bernard V, Koster J, et al.
Significance of TP53 Mutation in Wilms Tumors with Diffuse Anaplasia: A Report from the
Children's Oncology Group
by Ooms AH, Gadd S, Gerhard DS, et al.
TCF21 hypermethylation in genetically quiescent clear cell sarcoma of the kidney by Gooskens SL, Gadd S, Guidry Auvil JM, et al.
The genetic landscape of high-risk neuroblastoma by Pugh TJ, Morozova O, Attiyeh EF, Asgharzadeh S, Wei JS, Auclair D, Carter SL, Cibulskis K,
Hanna M, Kiezun A, Kim J, Lawrence MS, Lichenstein L, et al.
The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia
by Yu Liu, John Easton, Ying Shao, et al.
The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural
alterations and age-specific mutational interactions
by Bolouri H, Farrar JE, Triche T Jr, et al.