Tabula Muris Senis

biology encyclopedic genomic health life sciences machine learning medicine single-cell transcriptomics

Description

Tabula Muris Senis is a comprehensive compendium of single cell transcriptomic data from the model organism Mus musculus comprising more than 500,000 cells from 18 organs and tissues across the mouse lifespan. We discovered cell-specific changes occurring across multiple cell types and organs, as well as age related changes in the cellular composition of different organs. Using single-cell transcriptomic data we were able to assess cell type specific manifestations of different hallmarks of aging, such as senescence, changes in the activity of metabolic pathways, depletion of stem-cell populations, genomic instability and the role of inflammation as well as other changes in the organism’s immune system. Tabula Muris Senis provides a wealth of new molecular information about how the most significant hallmarks of aging are reflected in a broad range of tissues and cell types.See: https://www.biorxiv.org/content/10.1101/661728v1

Update Frequency

This is the first version of the dataset and it will be updated after the manuscript has been peer reviewed.

License

https://github.com/czbiohub/tabula-muris-senis/blob/master/LICENSE

Documentation

https://github.com/czbiohub/tabula-muris-senis/blob/master/tabula-muris-senis-on-aws.md

Managed By

Chan Zuckerberg Biohub

See all datasets managed by Chan Zuckerberg Biohub.

Contact

If you have questions about the data, you can create an Issue at https://github.com/czbiohub/tabula-muris-senis.

Resources on AWS


Edit this dataset entry on GitHub

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