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genetic genomic life sciences sqlite tertiary analysis variant annotation


OpenCRAVAT is a module variant annotation tool developed by KarchinLab at Johns Hopkins. This dataset is a mirror of the OpenCRAVAT store available at You can configure OpenCRAVAT to use this mirror by editing the "cravat-system.yml" file. The path to this file is in the first output line of the command "oc config system". In that file, change the value of "store_url" to "".

Update Frequency

Data is mirrored daily. Update frequencies of individual annotators depend on the update schedule of the source data.


License varies per-annotator. Commercial users must check the "commercial_warning" field in the module_name.yml file of each annotator.


Managed By

KarchinLab, Potomac IT Group

See all datasets managed by KarchinLab, Potomac IT Group.


How to Cite

OpenCRAVAT was accessed on DATE from Pagel KA, Kim R, Moad K, Busby B, Zheng L, Tokheim C, Ryan M, Karchin R. (2020) Integrated informatics analysis of cancer-related variants. JCO CCI Mar;4:310-317. doi: 10.1200/CCI.19.00132.

Usage Examples

Tools & Applications

Resources on AWS

  • Description
    OpenCRAVAT Store US
    Resource type
    S3 Bucket
    Amazon Resource Name (ARN)
    AWS Region
    AWS CLI Access (No AWS account required)
    aws s3 ls --no-sign-request s3://opencravat-store-aws/
  • Description
    OpenCRAVAT Store EU
    Resource type
    S3 Bucket
    Amazon Resource Name (ARN)
    AWS Region
    AWS CLI Access (No AWS account required)
    aws s3 ls --no-sign-request s3://opencravat-store-eu-west-2/

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