The Mount Sinai PsychAD Study (MSSM_PsychAD)

Description

The Mount Sinai PsychAD Study provides population-scale single-nucleus RNA sequencing data from the dorsolateral prefrontal cortex of 1,494 postmortem brain donors. The study encompasses more than 6.3 million nuclei from individuals with neurodegenerative diseases, serious mental illnesses, and neurotypical controls. Represented conditions include Alzheimer's disease, Parkinson's disease, schizophrenia, bipolar disorder, diffuse Lewy body dementia, vascular dementia, and additional neurological and psychiatric disorders. The study also includes genotype, clinical, neuropathological, and neuropsychiatric symptom data where available.

Update Frequency

AD Knowledge Portal Data Releases are published monthly (https://news.adknowledgeportal.org/). Updates to specific studies are dependent on data contributor and ingress timelines.

License

https://adknowledgeportal.synapse.org/Explore/Studies/DetailsPage/StudyDetails?Study=syn52160016#Acknowledgement

Documentation

https://doi.org/10.7303/9618136

Managed By

Sage Bionetworks

See all datasets managed by Sage Bionetworks.

Contact

https://www.synapse.org/Synapse:syn2580853/discussion/default

How to Cite

The Mount Sinai PsychAD Study (MSSM_PsychAD) was accessed on DATE from https://registry.opendata.aws/mssm-psych-ad.

Usage Examples

Publications

• Cell Hashing with barcoded antibodies enables multiplexing and doublet detection for single cell genomics by Stoeckius M, Zheng S, Houck-Loomis B, Hao S, Yeung BZ, Mauck WM 3rd, et al.
  
• Population-scale cross-disorder atlas of the human prefrontal cortex at single-cell resolution by Fullard JF, Prashant NM, Lee D, Mathur D, Therrien K, Hong A, et al.