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Molecular Profiling to Predict Response to Treatment (phs001965)

cancer genomic life sciences STRIDES whole genome sequencing


The Molecular Profiling to Predict Response to Treatment (MP2PRT) program is part of the NCI's Cancer Moonshot Initiative. The aim of this program is the retrospective characterization and analysis of biospecimens collected from completed NCI-sponsored trials of the National Clinical Trials Network and the NCI Community Oncology Research Program. This study, titled "Identification of Genetic Changes Associated with Relapse and/or Adaptive Resistance in Patients Registered as Favorable Histology Wilms Tumor on AREN03B2", performs genomic characterization (WGS 30X, Total RNAseq, miRNAseq) on a discovery set of 70 trio cases (normal tissue, tumor tissue at time of diagnosis, tumor tissue at time of relapse) from patients who relapsed with Favorable Histology Wilms Tumor. Prioritized findings from the discovery set will be validated using Targeted Sequencing in an independent validation set of 47 relapse samples. The MP2PRT study is made available on AWS via the NIH STRIDES Initiative (

Update Frequency

Genomic Data Commons (GDC) is source of truth for this dataset; GDC offers monthly data releases, although this dataset may not be updated at every release.


NIH Genomic Data Sharing Policy


Managed By

See all datasets managed by Center for Translational Data Science at The University of Chicago.


How to Cite

Molecular Profiling to Predict Response to Treatment (phs001965) was accessed on DATE from In addition, please cite the following grants in any publication that cites this data: U10CA180886 (NCTN Operations Center Grant); 1U24-CA196173 (Human Specimen Banking in NCI-Sponsored Clinical Trials); U10CA180899 (NCTN Statistics & Data Center)

Usage Examples

Tools & Applications

Resources on AWS

  • Description
    miRNA Sequencing, Total RNA Sequencing, Whole Genome Sequencing, Targeted Sequencing
    Resource type
    S3 Bucket
    Amazon Resource Name (ARN)
    AWS Region
    AWS CLI Access (No AWS account required)
    aws s3 ls --no-sign-request s3://gdc-mp2prt-wt-phs001965-2-open/

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