The MIT ROSMAP Single-Nucleus Multiomics Study (MIT_ROSMAP_Multiomics)

Description

The MIT ROSMAP Single-Nucleus Multiomics Study provides single-nucleus transcriptomic and chromatin accessibility data generated from postmortem brain tissue from participants in the Religious Orders Study and Rush Memory and Aging Project (ROSMAP). The study includes single-nucleus RNA sequencing, single-nucleus ATAC sequencing, and paired multiome data from 427 prefrontal cortex samples, as well as single-nucleus RNA sequencing data from multiple brain regions. These data support investigation of cell-type-specific molecular changes, cellular vulnerability, cognitive resilience, and Alzheimer's disease progression.

Update Frequency

AD Knowledge Portal Data Releases are published monthly (https://news.adknowledgeportal.org/). Updates to specific studies are dependent on data contributor and ingress timelines.

License

https://adknowledgeportal.synapse.org/Explore/Studies/DetailsPage/StudyDetails?Study=syn52293417#Acknowledgement

Documentation

https://doi.org/10.7303/9618323

Managed By

Sage Bionetworks

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Contact

https://www.synapse.org/Synapse:syn2580853/discussion/default

How to Cite

The MIT ROSMAP Single-Nucleus Multiomics Study (MIT_ROSMAP_Multiomics) was accessed on DATE from https://registry.opendata.aws/mit-rosmap.

Usage Examples

Publications

• Single-cell atlas reveals correlates of high cognitive function, dementia, and resilience to Alzheimer's disease pathology by Mathys H, Peng Z, Boix CA, Victor MB, Leary N, Babu S, et al.