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Human Cancer Models Initiative (HCMI) Cancer Model Development Center

cancer genomic life sciences STRIDES whole genome sequencing


The Human Cancer Models Initiative (HCMI) is an international consortium that is generating novel, next-generation, tumor-derived culture models annotated with genomic and clinical data. HCMI-developed models and related data are available as a community resource. The NCI is contributing to the initiative by supporting four Cancer Model Development Centers (CMDCs). CMDCs are tasked with producing next-generation cancer models from clinical samples. The cancer models include tumor types that are rare, originate from patients from underrepresented populations, lack precision therapy, or lack cancer model tools. Throughout the development process, the CMDCs utilize stringent internal QC measures to ensure both clinical and molecular integrity. These models are then annotated with clinical and genomic data and are available as a community resource.

Update Frequency

Genomic Data Commons (GDC) is source of truth for this dataset; GDC offers monthly data releases, although this dataset may not be updated at every release.


NIH Genomic Data Sharing Policy


Managed By

See all datasets managed by Center for Translational Data Science at The University of Chicago.


How to Cite

Human Cancer Models Initiative (HCMI) Cancer Model Development Center was accessed on DATE from

Usage Examples

Tools & Applications

Resources on AWS

  • Description
    Biospecimen Supplement, RNA-Seq Gene Expression Quantification
    Resource type
    S3 Bucket
    Amazon Resource Name (ARN)
    AWS Region
    AWS CLI Access (No AWS account required)
    aws s3 ls --no-sign-request s3://gdc-hcmi-cmdc-phs001486-2-open/

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