Encyclopedia of DNA Elements (ENCODE)

bioinformatics biology deep learning genetic genomic life sciences machine learning


The Encyclopedia of DNA Elements (ENCODE) Consortium is an international collaboration of research groups funded by the National Human Genome Research Institute (NHGRI). The goal of ENCODE is to build a comprehensive parts list of functional elements in the human genome, including elements that act at the protein and RNA levels, and regulatory elements that control cells and circumstances in which a gene is active. ENCODE investigators employ a variety of assays and methods to identify functional elements. The discovery and annotation of gene elements is accomplished primarily by sequencing a diverse range of RNA sources, comparative genomics, integrative bioinformatic methods, and human curation. Regulatory elements are typically investigated through DNA hypersensitivity assays, assays of DNA methylation, and immunoprecipitation (IP) of proteins that interact with DNA and RNA, i.e., modified histones, transcription factors, chromatin regulators, and RNA-binding proteins, followed by sequencing.

Update Frequency



External data users may freely download, analyze, and publish results based on any ENCODE data without restrictions.



Managed By

ENCODE Data Coordinating Center

See all datasets managed by ENCODE Data Coordinating Center.



How to Cite

Encyclopedia of DNA Elements (ENCODE) was accessed on DATE from https://registry.opendata.aws/encode-project.

Usage Examples


Resources on AWS

  • Description
    Released and archived ENCODE data
    Resource type
    S3 Bucket
    Amazon Resource Name (ARN)
    AWS Region
    AWS CLI Access (No AWS account required)
    aws s3 ls s3://encode-public/ --no-sign-request

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