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CIViC (Clinical Interpretation of Variants in Cancer)

genetic genomic life sciences vcf


Precision medicine refers to the use of prevention and treatment strategies that are tailored to the unique features of each individual and their disease. In the context of cancer this might involve the identification of specific mutations shown to predict response to a targeted therapy. The biomedical literature describing these associations is large and growing rapidly. Currently these interpretations exist largely in private or encumbered databases resulting in extensive repetition of effort. Realizing precision medicine will require this information to be centralized, debated and interpreted for application in the clinic. CIViC is an open access, open source, community-driven web resource for Clinical Interpretation of Variants in Cancer. Our goal is to enable precision medicine by providing an educational forum for dissemination of knowledge and active discussion of the clinical significance of cancer genome alterations.

Update Frequency

First of each month




Managed By

The McDonnell Genome Institute at Washington University School of Medicine

See all datasets managed by The McDonnell Genome Institute at Washington University School of Medicine.


How to Cite

CIViC (Clinical Interpretation of Variants in Cancer) was accessed on DATE from

Usage Examples


Resources on AWS

  • Description
    Monthly CIViC data dumps including gene, variant, assertion, and evidence tables.
    Resource type
    S3 Bucket
    Amazon Resource Name (ARN)
    AWS Region
    AWS CLI Access (No AWS account required)
    aws s3 ls --no-sign-request s3://civic-aws-opendata/

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