BrainSeq - Neurogenomics to Drive Novel Target Discovery for Neuropsychiatric Disorders

Description

This ambitious project seeks to characterize the genetic and epigenetic regulation of multiple facets of transcription in distinct brain regions across the human lifespan in samples of major neuropsychiatric disorders and controls. Initially focused on schizophrenia and mood disorders, the goal of this consortium is to elucidate the underlying molecular mechanisms of genetic associations with the goal of identifying novel therapeutic targets. The consortium currently consists of seven pharmaceutical companies and a not-for-profit medical research institution working as a precompetitive team to generate and analyze publicly available archival brain genomic data related to neuropsychiatric illness.

Update Frequency

Never

License

CC BY

Documentation

https://www.synapse.org/#!Synapse:syn12299750/wiki/551288

Managed By

Sage Bionetworks

See all datasets managed by Sage Bionetworks.

Contact

lcolladotor@gmail.com

How to Cite

BrainSeq - Neurogenomics to Drive Novel Target Discovery for Neuropsychiatric Disorders was accessed on DATE from https://registry.opendata.aws/brainseq. Jaffe AE, Straub RE, Shin JH, Tao R, Gao Y, Collado-Torres L, Kam-Thong T, Xi HS, Quan J, Chen Q, Colantuoni C, Ulrich WS, Maher BJ, Deep-Soboslay A; BrainSeq Consortium; Cross AJ, Brandon NJ, Leek JT, Hyde TM, Kleinman JE, Weinberger DR. Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia pathogenesis. Nat Neurosci. 2018 Aug;21(8):1117-1125. doi: 10.1038/s41593-018-0197-y. Epub 2018 Jul 26.

Usage Examples

Tools & Applications

• BrainSeq Phase1 DLPFC by Jaffe A, Straub R, Shin J, Tao R, Gao Y, Collado-Torres L, et al
  

Publications

• Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia pathogenesis by Jaffe A, Straub R, Shin J, Tao R, Gao Y, Collado-Torres L, et al