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Seattle Alzheimer's Disease Brain Cell Atlas (SEA-AD)

biology cell biology cell imaging epigenomics gene expression histopathology Homo sapiens imaging medicine microscopy neurobiology neuroscience single-cell transcriptomics transcriptomics

Description

The Seattle Alzheimer's Disease Brain Cell Atlas (SEA-AD) consortium strives to gain a deep molecular and cellular understanding of the early pathogenesis of Alzheimer's disease and is funded by the National Institutes on Aging (NIA U19AG060909). The SEA-AD datasets available here comprise single cell profiling (transcriptomics and epigenomics) and quantitative neuropathology. To explore gene expression and chromatin accessibility information, the single-cell profiling data includes: snRNAseq and snATAC-seq data from the SEA-AD donor cohort (aged brains which span the spectrum of Alzheimer's Disease pathology) and neurotypical reference brains. To explore key pathological proteins and cell types of interest to Alzheimer's disease, the neuropathology data includes: full resolution brightfield images, images processed and segmented in HALO image analysis software, image annotations, and quantification summary files for the relevant stains including Abeta (6E10), IBA1, a-Synuclein, GFAP, H&E-LFB, NeuN, pTau(AT8), and pTDP43.

Update Frequency

Annually

License

https://alleninstitute.org/legal/terms-use/

Documentation

https://portal.brain-map.org/explore/seattle-alzheimers-disease/seattle-alzheimers-disease-brain-cell-atlas-download?edit&language=en

Managed By

See all datasets managed by Allen Institute.

Contact

awspublicdataset@alleninstitute.org

How to Cite

Seattle Alzheimer's Disease Brain Cell Atlas (SEA-AD) was accessed on DATE from https://registry.opendata.aws/allen-sea-ad-atlas.

Usage Examples

Tools & Applications

Resources on AWS

  • Description
    Single cell profiling (transcriptomics and epigenomics) data files in a public bucket
    Resource type
    S3 Bucket
    Amazon Resource Name (ARN)
    arn:aws:s3:::sea-ad-single-cell-profiling
    AWS Region
    us-west-2
    AWS CLI Access (No AWS account required)
    aws s3 ls --no-sign-request s3://sea-ad-single-cell-profiling/
    Explore
    Browse Bucket
  • Description
    Quantitative neuropathology (full resolution images, processed images, and quantifications) in a public bucket
    Resource type
    S3 Bucket
    Amazon Resource Name (ARN)
    arn:aws:s3:::sea-ad-quantitative-neuropathology
    AWS Region
    us-west-2
    AWS CLI Access (No AWS account required)
    aws s3 ls --no-sign-request s3://sea-ad-quantitative-neuropathology/
    Explore
    Browse Bucket
  • Description
    Spatial transcriptomics data files in a public bucket
    Resource type
    S3 Bucket
    Amazon Resource Name (ARN)
    arn:aws:s3:::sea-ad-spatial-transcriptomics
    AWS Region
    us-west-2
    AWS CLI Access (No AWS account required)
    aws s3 ls --no-sign-request s3://sea-ad-spatial-transcriptomics/
    Explore
    Browse Bucket

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